Detalhe da pesquisa
1.
Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets.
Mol Cell
; 81(13): 2722-2735.e9, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34077757
2.
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells.
Mol Cell
; 81(11): 2303-2316.e8, 2021 06 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33991485
3.
Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression.
Nat Chem Biol
; 2024 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38538923
4.
Designing antimicrobial peptides using deep learning and molecular dynamic simulations.
Brief Bioinform
; 24(2)2023 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36857616
5.
Design, synthesis, and mechanism of action of novel µ-conotoxin KIIIA analogues for inhibition of the voltage-gated sodium channel Nav1.7.
J Biol Chem
; 299(4): 103068, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36842500
6.
Rational design and synthesis of triazene-amonafide derivatives as novel potential antitumor agents causing oxidative damage towards DNA through intercalation mode.
Bioorg Chem
; 144: 107141, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38244381
7.
Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors.
Mar Drugs
; 22(3)2024 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38535451
8.
De novo design of dual-target JAK2, SMO inhibitors based on deep reinforcement learning, molecular docking and molecular dynamics simulations.
Biochem Biophys Res Commun
; 638: 23-27, 2023 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36436338
9.
Electrochemical detection of the oxidative damage of a potential pyrimido[5,4-g]pteridine-derived antitumor agent toward DNA.
Anal Bioanal Chem
; 415(12): 2249-2260, 2023 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-36920495
10.
Design, Synthesis, and Biological Evaluation of Marine Lissodendrins B Analogues as Modulators of ABCB1-Mediated Multidrug Resistance.
Mar Drugs
; 21(5)2023 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37233508
11.
Molecular Dynamic Simulations Reveal the Activation Mechanisms of Oxidation-Induced TRPV1.
Int J Mol Sci
; 24(11)2023 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37298504
12.
Virtual screening and molecular dynamics simulation for identification of natural antiviral agents targeting SARS-CoV-2 NSP10.
Biochem Biophys Res Commun
; 626: 114-120, 2022 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35988295
13.
Design, synthesis, and bioactivity study on Lissodendrins B derivatives as PARP1 inhibitor.
Bioorg Med Chem
; 69: 116892, 2022 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35764034
14.
Design, Synthesis and Evaluation of Novel Phorbazole C Derivatives as MNK Inhibitors through Virtual High-Throughput Screening.
Mar Drugs
; 20(7)2022 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35877722
15.
Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human α3ß4 Nicotinic Acetylcholine Receptor.
Mar Drugs
; 20(8)2022 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-36005500
16.
Unusual Tetrahydropyridoindole-Containing Tetrapeptides with Human Nicotinic Acetylcholine Receptors Targeting Activity Discovered from Antarctica-Derived Psychrophilic Pseudogymnoascus sp. HDN17-933.
Mar Drugs
; 20(10)2022 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36286417
17.
Design, Synthesis and Structure-Activity Relationship Studies of Meridianin Derivatives as Novel JAK/STAT3 Signaling Inhibitors.
Int J Mol Sci
; 23(4)2022 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35216314
18.
Identification of inhibitors targeting HIF-2α/c-Myc by molecular docking and MM-GBSA technology.
J Recept Signal Transduct Res
; 41(5): 511-519, 2021 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-32981413
19.
Author Correction: Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression.
Nat Chem Biol
; 2024 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38649455
20.
Blockade of Human α7 Nicotinic Acetylcholine Receptor by α-Conotoxin ImI Dendrimer: Insight from Computational Simulations.
Mar Drugs
; 17(5)2019 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31126085